反応式
[CH3:1][O:2][C:3]1[CH:7]=[C:6]([CH2:8]O)[O:5][N:4]=1.C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1.C(Br)(Br)(Br)[Br:30]>ClCCl>[Br:30][CH2:8][C:6]1[O:5][N:4]=[C:3]([O:2][CH3:1])[CH:7]=1参加物
5
反応条件
- 温度
- 0 °C
実験手順
(3-Methoxy-isoxazol-5-yl)-methanol (822 mg, 6.4 mmol) was dissolved in dichloromethane (10 ml) and triphenyl phosphine (1.84 g, 7.0 mmol) and carbon tetrabromide (2 g, 6.11 mmol) were added at 0° C. The mixture was stirred for 2 hours at 0° C. and concentrated. The crude product was purified by chromatography on silica gel (eluent: ethyl acetate/hexane) to give the product as a colourless oil (1.22 g, 99% yield) which was used in the next step without further purification.
後処理
- concentrationconcentrated
- customThe crude product was purified by chromatography on silica gel (eluent: ethyl acetate/hexane)
出典と根拠
- ORDレコード
- ord-24116bc5d2954304a1842115c55f4903
- 出典データセット
- uspto-grants-2014_03
- 特許番号
- US08680290B2
関連ノート
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