2-Chloro-4-(trifluoromethyl)pyrimidine → (1R,6S)-8-(6-Methylpyrazin-2-yl)-3,8-diazabicyclo[4.2.0]octane

反応式

F[C:2](F)(F)[C:3]1[CH:8]=CN=[C:5]([N:9]2[C@@H:16]3[C@@H:11]([CH2:12][CH2:13][NH:14][CH2:15]3)[CH2:10]2)[N:4]=1.Cl[C:20]1N=C(C(F)(F)F)C=C[N:21]=1>>[CH3:2][C:3]1[N:4]=[C:5]([N:9]2[C@@H:16]3[C@@H:11]([CH2:12][CH2:13][NH:14][CH2:15]3)[CH2:10]2)[CH:20]=[N:21][CH:8]=1

参加物

反応物 2

HCID 27739122-Chloro-4-(trifluoromethyl)pyrimidine

HCID 67116508HCID 67116508、化合物

生成物 1

HCID 67116766(1R,6S)-8-(6-Methylpyrazin-2-yl)-3,8-diazabicyclo[4.2.0]octane

実験手順

The title compound was prepared in a manner analogous to Intermediate 27, substituting 2-bromo-6-methylpyrazine for 2-chloro-4-(trifluoromethyl)pyrimidine.

出典と根拠

ORDレコード: ord-79feb94a1b794e679851b03168bf67d9
出典データセット: uspto-grants-2014_03
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US08680275B2

反応ノート

読み込み中…