HCID 66798915、化合物 → N,N-Dimethyl-4-(4-(methylamino)piperidin-1-yl)pyridin-2-amine

HRID 1193375ノート

反応式

HRID 1193375 の反応式
[CH3:1][N:2]([CH3:27])[C:3]1[CH:8]=[C:7]([N:9]2[CH2:14][CH2:13][CH:12]([N:15](C)[C:16](=O)OCC3C=CC=CC=3)[CH2:11][CH2:10]2)[CH:6]=[CH:5][N:4]=1>CO>[CH3:1][N:2]([CH3:27])[C:3]1[CH:8]=[C:7]([N:9]2[CH2:10][CH2:11][CH:12]([NH:15][CH3:16])[CH2:13][CH2:14]2)[CH:6]=[CH:5][N:4]=1

参加物

3

反応物 1

HCID 66798915HCID 66798915、化合物

生成物 1

HCID 66798588N,N-Dimethyl-4-(4-(methylamino)piperidin-1-yl)pyridin-2-amine収率 96%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

Benzyl 1-(2-(dimethylamino)pyridin-4-yl)piperidin-4-yl(methyl)carbamate (280 mg, 0.76 mmol, 1.0 eq.) was dissolved in MeOH (10 ml) and degassed with N2. Pd(OH)2 (140 mg, 50%) was then added and hydrogenation was carried out for 3 hours. After monitoring by TLC, the reaction mixture was filtered over Celite, the filtrate was concentrated under reduced pressure and the crude product was used in the next stage without being purified further. Yield: 96% (170 mg, 0.726 mmol)

後処理

  1. customdegassed with N2
  2. additionPd(OH)2 (140 mg, 50%) was then added
  3. filtrationthe reaction mixture was filtered over Celite
  4. concentrationthe filtrate was concentrated under reduced pressure
  5. customwithout being purified further

出典と根拠

ORDレコード
ord-33c461506ca741068a3f983b182245b4
出典データセット
uspto-grants-2014_03
特許番号
US08680159B2

反応ノート

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