tert-Butyl (1-benzylpiperidin-4-yl)methylcarbamate → 4-N-Boc-4-N-Methyl-aminopiperidine

HRID 1193389ノート

反応式

HRID 1193389 の反応式
C([N:8]1[CH2:13][CH2:12][CH:11]([N:14]([CH3:22])[C:15](=[O:21])[O:16][C:17]([CH3:20])([CH3:19])[CH3:18])[CH2:10][CH2:9]1)C1C=CC=CC=1>CO>[CH3:22][N:14]([CH:11]1[CH2:10][CH2:9][NH:8][CH2:13][CH2:12]1)[C:15](=[O:21])[O:16][C:17]([CH3:20])([CH3:18])[CH3:19]

参加物

3

反応物 1

HCID 18476608tert-Butyl (1-benzylpiperidin-4-yl)methylcarbamate

生成物 1

HCID 27568064-N-Boc-4-N-Methyl-aminopiperidine収率 85%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

tert-Butyl 1-benzylpiperidin-4-yl(methyl)carbamate (1.0 g, 3.289 mmol, 1.0 eq.) was dissolved in MeOH (15 ml) and degassed with argon. Pd/C (300 mg) was then added and hydrogenation was carried out for 4 hours. After monitoring by TLC, the reaction mixture was filtered over Celite and the filtrate was concentrated under reduced pressure. The crude product was used in the next stage without being purified further. Yield: 85% (600 mg, 2.803 mmol)

後処理

  1. customdegassed with argon
  2. additionPd/C (300 mg) was then added
  3. filtrationthe reaction mixture was filtered over Celite
  4. concentrationthe filtrate was concentrated under reduced pressure
  5. customwithout being purified further

出典と根拠

ORDレコード
ord-7367616cf3984297a5c4518a2954ef88
出典データセット
uspto-grants-2014_03
特許番号
US08680159B2

反応ノート

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