Methyl isothiocyanate → HCID 86663381、化合物

HRID 1193392ノート

反応式

HRID 1193392 の反応式
[CH3:1][N:2]=[C:3]=[S:4].[CH3:5][N:6]([CH:17]1[CH2:22][CH2:21][NH:20][CH2:19][CH2:18]1)[C:7](=[O:16])[O:8][CH2:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1>ClCCl>[CH3:5][N:6]([CH:17]1[CH2:18][CH2:19][N:20]([C:3](=[S:4])[NH:2][CH3:1])[CH2:21][CH2:22]1)[C:7](=[O:16])[O:8][CH2:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1

参加物

4

反応物 2

HCID 11167Methyl isothiocyanateHCID 18677746Benzyl methyl(piperidin-4-yl)carbamate

生成物 1

HCID 86663381HCID 86663381、化合物収率 45%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

A solution of methyl isothiocyanate (500 mg, 6.8493 mmol, 1 eq) in dichloromethane (4 ml) was added dropwise over a period of 5 min to a solution of benzyl methyl(piperidin-4-yl)carbamate (stage 3 AMN-52) (1.7 g, 6.8493 mmol, 1 eq). When the addition was complete, the reaction mixture was stirred for 20 hours at room temperature. Concentration under reduced pressure was then carried out and the crude product was purified by column chromatography (silica gel, 2% methanol in dichloromethane). Yield: 45% (1 g, 3.115 mmol)

後処理

  1. additionWhen the addition
  2. concentrationConcentration under reduced pressure
  3. customthe crude product was purified by column chromatography (silica gel, 2% methanol in dichloromethane)

出典と根拠

ORDレコード
ord-6ac9c05858274756aebffa91cb4db4c4
出典データセット
uspto-grants-2014_03
特許番号
US08680159B2

反応ノート

読み込み中…