1-Bromo-3-chloropropane → N-[3-(3-Chloropropoxy)phenyl]urea
反応式
[OH:1][C:2]1[CH:3]=[C:4]([NH:8][C:9]([NH2:11])=[O:10])[CH:5]=[CH:6][CH:7]=1.Br[CH2:13][CH2:14][CH2:15][Cl:16].C(=O)([O-])[O-].[K+].[K+]>CC(C)=O>[Cl:16][CH2:15][CH2:14][CH2:13][O:1][C:2]1[CH:3]=[C:4]([NH:8][C:9]([NH2:11])=[O:10])[CH:5]=[CH:6][CH:7]=1参加物
5
実験手順
A mixture of 45.6 g (0.3 mole) of 1-(3-hydroxyphenyl)urea, 94.5 g (0.6 mole) of 1-bromo-3-chloropropane, 124.4 g (0.9 mole) of anhydrous potassium carbonate and 1 liter of acetone was heated at reflux with mechanical stirring for 20 hr. The mixture was concentrated and the residue was slurried with 1.5 liters of water. The mixture was filtered and the filter cake was recrystallized from isopropanol to yield 57.0 g (83%) of off-white solid, m.p. 141°-143° C.
後処理
- temperaturewas heated
- temperatureat reflux
- concentrationThe mixture was concentrated
- filtrationThe mixture was filtered
- customthe filter cake was recrystallized from isopropanol
出典と根拠
- ORDレコード
- ord-58d5f522eb864f38ac8325b0bf7b2394
- 出典データセット
- uspto-grants-1989_03
- 特許番号
- US04810713
反応ノート
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