Sodium Methoxide → 1-(4-chloro-2-fluoro-5-isopropoxyphenyl)-5-fluoro-2-methoxy-4-trifluoromethyl-6(1H)-pyrimidinone
反応式
Cl[C:2]1[N:3]([C:14]2[CH:19]=[C:18]([O:20][CH:21]([CH3:23])[CH3:22])[C:17]([Cl:24])=[CH:16][C:15]=2[F:25])[C:4](=[O:13])[C:5]([F:12])=[C:6]([C:8]([F:11])([F:10])[F:9])[N:7]=1.[CH3:26][O-:27].[Na+]>CO>[Cl:24][C:17]1[C:18]([O:20][CH:21]([CH3:23])[CH3:22])=[CH:19][C:14]([N:3]2[C:4](=[O:13])[C:5]([F:12])=[C:6]([C:8]([F:11])([F:10])[F:9])[N:7]=[C:2]2[O:27][CH3:26])=[C:15]([F:25])[CH:16]=1参加物
4
実験手順
using 2-chloro-1-(4-chloro-2-fluoro-5 -isopropoxyphenyl)-5-fluoro-4-trifluoromethyl-6(1H)-pyrimidinone and sodium methylate in methanol there is obtained 1-(4-chloro-2-fluoro-5-isopropoxyphenyl)-5 -fluoro-2-methoxy-4-trifluoromethyl-6(1H)-pyrimidinone, m.p. 144°-146° C.;