Sulfuric Acid → 1-(4-chloro-2-fluoro-5-hydroxyphenyl)-5-fluoro-2-methoxy-4-trifluoromethyl-6(1H)-pyrimidinone
反応式
[Cl:1][C:2]1[C:7]([O:8]C(C)C)=[CH:6][C:5]([N:12]2[C:17](=[O:18])[C:16]([F:19])=[C:15]([C:20]([F:23])([F:22])[F:21])[N:14]=[C:13]2[O:24][CH3:25])=[C:4]([F:26])[CH:3]=1.S(=O)(=O)(O)O>>[Cl:1][C:2]1[C:7]([OH:8])=[CH:6][C:5]([N:12]2[C:17](=[O:18])[C:16]([F:19])=[C:15]([C:20]([F:23])([F:21])[F:22])[N:14]=[C:13]2[O:24][CH3:25])=[C:4]([F:26])[CH:3]=1参加物
3
実験手順
using 1-(4-chloro-2-fluoro-5-isopropoxyphenyl)-5-fluoro-2-methoxy-4-trifluoromethyl-6(1H)-pyrimidinone with concentrated sulphuric acid during 2 minutes at 0° C. there is obtained 1-(4-chloro-2-fluoro-5-hydroxyphenyl)-5-fluoro-2-methoxy-4-trifluoromethyl-6(1H)-pyrimidinone, 1H14 NMR (CDCl3, 400 MHz): 7.30 ppm (d,1H), 6.87 ppm (d,1H), 4.00 ppm (s,3H);
後処理
- customduring 2 minutes
- customat 0° C.