Morpholine → 2-(2-Hydroxyphenyl)-1-(4-morpholinyl)ethanone

HRID 1194000

反応式

HRID 1194000 の反応式
[NH:1]1[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1.[O:7]1[C:11]2[CH:12]=[CH:13][CH:14]=[CH:15][C:10]=2[CH2:9][C:8]1=[O:16]>C(O)C>[OH:7][C:11]1[CH:12]=[CH:13][CH:14]=[CH:15][C:10]=1[CH2:9][C:8]([N:1]1[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1)=[O:16]

参加物

4

反応物 2

HCID 8083MorpholineHCID 683822(3H)-Benzofuranone

生成物 1

HCID 147733702-(2-Hydroxyphenyl)-1-(4-morpholinyl)ethanone収率 90.9%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

27.3 g of morpholine are added in a single portion to a solution of 30 g of 2,3-dihydro-2-benzofuranone in 100 ml of ethanol, and the medium is stirred for 1 hour. The solvent is evaporated off under vacuum, the residual gum is taken up in isopropyl ether in the hot state and the medium is allowed to return to room temperature. The crystallized product is filtered, washed with isopropyl ether and dried. 45 g of white crystallized product are obtained.

後処理

  1. customThe solvent is evaporated off under vacuum
  2. customto return to room temperature
  3. filtrationThe crystallized product is filtered
  4. washwashed with isopropyl ether
  5. customdried

出典と根拠

ORDレコード
ord-924612fcc2e142f389e5135b6236698f
出典データセット
uspto-grants-1989_03
特許番号
US04812469

関連ノート

読み込み中…