5-Aminoisoquinoline → 5-Amino-1,2,3,4-tetrahydroisoquinoline

HRID 1194100ノート

反応式

HRID 1194100 の反応式
[NH2:1][C:2]1[CH:11]=[CH:10][CH:9]=[C:8]2[C:3]=1[CH:4]=[CH:5][N:6]=[CH:7]2.[H][H]>C(O)(=O)C.[Pt]=O>[NH2:1][C:2]1[CH:11]=[CH:10][CH:9]=[C:8]2[C:3]=1[CH2:4][CH2:5][NH:6][CH2:7]2

参加物

5

反応物 2

HCID 707665-AminoisoquinolineHCID 178418361HCID 178418361、化合物

生成物 1

HCID 162174995-Amino-1,2,3,4-tetrahydroisoquinoline

試薬・触媒・溶媒 2

HCID 82844Platinum oxide (PtO)触媒HCID 176Acetic Acid溶媒

実験手順

A solution of 5-aminoisoquinoline (20 g) in glacial acetic acid (500 ml) was shaken under hydrogen in the presence of a platinum oxide catalyst (2.0 g) at room temperature and approximately 345 kilopascals pressure until uptake of hydrogen stopped. The catalyst was removed by filtration and the filtrate was evaporated to a small volume under reduced pressure. Residual solvent was removed by co-evaporation with water, then isopropyl alcohol, and the resulting solid was recrystallized from isopropyl alcohol to give 5-amino-1,2,3,4-tetrahydroisoquinoline as a white solid, 19 g, m.p. 153°-154° C.

後処理

  1. customThe catalyst was removed by filtration
  2. customthe filtrate was evaporated to a small volume under reduced pressure
  3. customResidual solvent was removed by co-evaporation with water
  4. customisopropyl alcohol, and the resulting solid was recrystallized from isopropyl alcohol

出典と根拠

ORDレコード
ord-8186bc04f14c47bcbe302433515f8a22
出典データセット
uspto-grants-1989_03
特許番号
US04812573

反応ノート

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