1-(triphenylmethyl)-1H-imidazole-4-carbaldehyde → HCID 14520344、化合物

HRID 1194370

反応式

HRID 1194370 の反応式
Br[C:2]1[CH:11]=[CH:10][C:5]2[O:6][CH2:7][O:8][CH2:9][C:4]=2[CH:3]=1.[C:12]1([C:18]([C:32]2[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=2)([C:26]2[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=2)[N:19]2[CH:23]=[C:22]([CH:24]=[O:25])[N:21]=[CH:20]2)[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1>>[O:6]1[C:5]2[CH:10]=[CH:11][C:2]([CH:24]([C:22]3[N:21]=[CH:20][N:19]([C:18]([C:12]4[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=4)([C:26]4[CH:27]=[CH:28][CH:29]=[CH:30][CH:31]=4)[C:32]4[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=4)[CH:23]=3)[OH:25])=[CH:3][C:4]=2[CH2:9][O:8][CH2:7]1

参加物

3

反応物 2

HCID 6182331-(triphenylmethyl)-1H-imidazole-4-carbaldehydeHCID 145203376-Bromo-4H-1,3-benzodioxine

生成物 1

HCID 14520344HCID 14520344、化合物収率 53%

実験手順

This compound is prepared like the preceding compound but starting from 6-bromo-4H-1,3-benzodioxin and 1-triphenylmethyl-1H-imidazole-4-carboxaldehyde. After decomposing the reaction mixture, the reaction product is extracted with dichloromethane and recrystallized from isopropyl alcohol. By chromatography of the residue obtained after evaporation of the mother liquors, there is obtained a second crop of product. Yield: 53% of theory; M.P.: 165°-167° C.

後処理

  1. customThis compound is prepared like the preceding compound
  2. extractionthe reaction product is extracted with dichloromethane
  3. customrecrystallized from isopropyl alcohol
  4. customBy chromatography of the residue obtained
  5. customafter evaporation of the mother liquors
  6. customthere is obtained a second crop of product

出典と根拠

ORDレコード
ord-8522ab1a0ab442ca861b3c58720b5f57
出典データセット
uspto-grants-1989_03
特許番号
US04814343

関連ノート

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