Glyoxylic Acid → Trans 4-(2,5-dimethyl-3-furyl)-4-oxo-2-butenoic Acid

HRID 1194391

反応式

HRID 1194391 の反応式
[C:1]([C:4]1[CH:8]=[C:7]([CH3:9])[O:6][C:5]=1[CH3:10])(=[O:3])[CH3:2].[C:11]([OH:15])(=[O:14])[CH:12]=O>O>[CH3:10][C:5]1[O:6][C:7]([CH3:9])=[CH:8][C:4]=1[C:1](=[O:3])/[CH:2]=[CH:12]/[C:11]([OH:15])=[O:14]

参加物

4

反応物 2

HCID 760Glyoxylic AcidHCID 615273-Acetyl-2,5-dimethylfuran

生成物 1

HCID 13565867Trans 4-(2,5-dimethyl-3-furyl)-4-oxo-2-butenoic Acid収率 14.2%

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

As in Example 1, one starts out with 9 g of 3-acetyl 2.5-dimethylfuran (J. Am. Chem. Soc., 70 739 (1948)), 6 g glyoxylic acid and 6 cm3 water. Following chromatography on silica (eluent: petroleum ether-ethyl acetate (2-8), recrystallization in ethyl acetate, 1.8 g of the expected product is obtained. MP=144°-147° C.

後処理

  1. custompetroleum ether-ethyl acetate (2-8), recrystallization in ethyl acetate

出典と根拠

ORDレコード
ord-4330fc5aab404c76bd4b258c5d74099b
出典データセット
uspto-grants-1989_03
特許番号
US04814348

関連ノート

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