Cyanoacetamide → HCID 13772058、化合物

HRID 1194495ノート

反応式

[C:1]([C:4]1[C:13]2[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=2)[C:7](=O)[NH:6][CH:5]=1)(=O)[CH3:2].[C:15](C1C=C(C2CCCCC2=O)C=CN=1)(=O)[CH3:16].[C:31]([CH2:33][C:34]([NH2:36])=[O:35])#[N:32]>>[C:31]([C:33]1[C:34](=[O:35])[NH:36][C:15]([CH3:16])=[C:1]2[C:4]=1[CH2:5][CH2:6][CH:7]([C:8]1[CH:9]=[CH:10][CH:11]=[CH:12][N:13]=1)[CH2:2]2)#[N:32]

参加物

反応物 3

HCID 7898Cyanoacetamide

HCID 131201644-Acetylisoquinolin-1(2H)-one

HCID 53904154HCID 53904154、化合物

生成物 1

HCID 13772058HCID 13772058、化合物

実験手順

Conventionally, these 4-acetyl isoquinolinone compounds have been prepared by condensing 2-acetyl-4-pyridyl cyclohexanone with cyanoacetamide to produce 4-cyano-1-methyl-7-pyridyl-5,6,7,8-tetrahydro-3(2H)-isoquinolinone and then reacting the obtained compound with a Grignard reagent such as methyl magnesium iodide and the like followed by decomposition by an acid.

出典と根拠

ORDレコード: ord-3226e4351414445cac0439f8100cc877
出典データセット: uspto-grants-1989_03
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US04814458

反応ノート

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