Triethylamine → 1,3-Dimethyl-4,6-dioxo-2-thioxo-N-[4-(4-trifluoromethylphenoxy)phenyl]perhydropyrimidine-5-carboxamide

HRID 1194657ノート

反応式

HRID 1194657 の反応式
[F:1][C:2]([F:20])([F:19])[C:3]1[CH:18]=[CH:17][C:6]([O:7][C:8]2[CH:13]=[CH:12][C:11]([N:14]=[C:15]=[O:16])=[CH:10][CH:9]=2)=[CH:5][CH:4]=1.[CH3:21][N:22]1[C:29](=[O:30])[CH2:28][C:26](=[O:27])[N:25]([CH3:31])[C:23]1=[S:24].C(N(CC)CC)C>C1C=CC=CC=1>[CH3:31][N:25]1[C:26](=[O:27])[CH:28]([C:15]([NH:14][C:11]2[CH:12]=[CH:13][C:8]([O:7][C:6]3[CH:17]=[CH:18][C:3]([C:2]([F:19])([F:20])[F:1])=[CH:4][CH:5]=3)=[CH:9][CH:10]=2)=[O:16])[C:29](=[O:30])[N:22]([CH3:21])[C:23]1=[S:24]

参加物

5

反応物 3

HCID 8471TriethylamineHCID 5989481,3-Dimethyl-2-sulfanylidene-1,3-diazinane-4,6-dioneHCID 131894424-(4'-Trifluoromethylphenoxy)phenyl isocyanate

生成物 1

HCID 140533731,3-Dimethyl-4,6-dioxo-2-thioxo-N-[4-(4-trifluoromethylphenoxy)phenyl]perhydropyrimidine-5-carboxamide

試薬・触媒・溶媒 1

HCID 241Benzene溶媒

実験手順

4-(4'-Trifluoromethylphenoxy)phenyl isocyanate (3.7 g.) was added to a stirred mixture of 1,3-dimethyl-2-thiobarbituric acid (2.3 g.) and triethylamine (1.7 ml.) in dry benzene (30 ml.). The mixture was refluxed for 12 hours. The mixture was evaporated in vacuo. Diethyl ether (10 ml.) was added to the gummy residue and the mixture was acidified with 1N hydrochloric acid. The mixture was filtered and the solid was washed with water and then ethanol.

後処理

  1. temperatureThe mixture was refluxed for 12 hours
  2. customThe mixture was evaporated in vacuo
  3. additionDiethyl ether (10 ml.) was added to the gummy residue
  4. filtrationThe mixture was filtered
  5. washthe solid was washed with water

出典と根拠

ORDレコード
ord-1fc0aa96892f4da8a81efcacb95ef557
出典データセット
uspto-grants-1989_03
特許番号
US04816460

反応ノート

読み込み中…