Sodium Chloride → 8-(1-Piperidinyl)-5,6,7,8-tetrahydroquinoline

HRID 1194703ノート

反応式

HRID 1194703 の反応式
[NH:1]1[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.Cl.Cl[CH:9]1[C:18]2[N:17]=[CH:16][CH:15]=[CH:14][C:13]=2[CH2:12][CH2:11][CH2:10]1.[Cl-].[Na+]>O>[N:1]1([CH:9]2[C:18]3[N:17]=[CH:16][CH:15]=[CH:14][C:13]=3[CH2:12][CH2:11][CH2:10]2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

参加物

5

反応物 3

HCID 5234Sodium ChlorideHCID 8082PiperidineHCID 137121818-Chloro-5,6,7,8-tetrahydroquinoline hydrochloride

生成物 1

HCID 200734668-(1-Piperidinyl)-5,6,7,8-tetrahydroquinoline

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

3.9 ml of piperidine were introduced into a solution of 2 g of 8-chloro-5,6,7,8-tetrahydroquinoline hydrochloride in 5 ml of water and the mixture was stirred for 15 minutes, heated for two-and-a-half hours at 57°±2° C., then cooled to ambient temperature. The medium was saturated with sodium chloride and extracted with ether. The solvent was eliminated under reduced presure to obtain 2.07 g of 8-(1-piperidinyl)-5,6,7,8-tetrahydroquinoline.

後処理

  1. temperatureheated for two-and-a-half hours at 57°±2° C.
  2. extractionextracted with ether

出典と根拠

ORDレコード
ord-c42a7f97c5f84aa5be0d576e540cb8e9
出典データセット
uspto-grants-1989_03
特許番号
US04816465

反応ノート

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