Hydrochloric Acid → (4-aminophenyl)-N-methylmethylenesulfonamide hydrochloride
反応式
[CH3:1][NH:2][S:3]([CH2:6][C:7]1[CH:12]=[CH:11][C:10]([N+:13]([O-])=O)=[CH:9][CH:8]=1)(=[O:5])=[O:4].[H][H].[ClH:18]>C(O)C.O.[Pd]=O>[ClH:18].[NH2:13][C:10]1[CH:11]=[CH:12][C:7]([CH2:6][S:3]([NH:2][CH3:1])(=[O:5])=[O:4])=[CH:8][CH:9]=1参加物
7
実験手順
A suspension of N-methyl-4-nitrobenzenemethanesulphonamide (30 g) in ethanol (150 ml), water (300 ml) and hydrochloric acid (2N, 65 ml) was hydrogenated over 10% palladium oxide on charcoal (7.5 g, 50% paste with water) until hydrogen uptake ceased (9.75 l). The catalyst was removed by filtration through "hyflo" and the filter pad was washed with water (30 ml). The filtrate was evaporated under reduced pressure to give the title compound as a pale yellow powder (28.2 g) m.p. 143°-144° C.
後処理
- customThe catalyst was removed by filtration through "hyflo"
- washthe filter pad was washed with water (30 ml)
- customThe filtrate was evaporated under reduced pressure
出典と根拠
- ORDレコード
- ord-ccdbfabfb80947ddaf33b139441bf3e6
- 出典データセット
- uspto-grants-1989_03
- 特許番号
- US04816470
反応ノート
読み込み中…
