Water → HCID 14865027、化合物

HRID 1194871ノート

反応式

HRID 1194871 の反応式
[CH:1]1([CH2:4][O:5]/[N:6]=[C:7](/[C:13]2[N:14]=[C:15]([NH:18]C(C3C=CC=CC=3)(C3C=CC=CC=3)C3C=CC=CC=3)[S:16][CH:17]=2)\[C:8]([O:10][CH2:11][CH3:12])=[O:9])[CH2:3][CH2:2]1.O>C(O)=O>[CH2:11]([O:10][C:8](=[O:9])/[C:7](/[C:13]1[N:14]=[C:15]([NH2:18])[S:16][CH:17]=1)=[N:6]\[O:5][CH2:4][CH:1]1[CH2:2][CH2:3]1)[CH3:12]

参加物

4

反応物 2

HCID 962WaterHCID 13269245HCID 13269245、化合物

生成物 1

HCID 14865027HCID 14865027、化合物収率 93%

試薬・触媒・溶媒 1

HCID 284Formic Acid溶媒

実験手順

Ethyl (Z)-2-cyclopropylmethoxyimino-2-(2-tritylaminothiazol-4-yl)acetate (2.39 g) was dissolved in 98% formic acid (18.7 ml), water (5.6 ml) was added, and the mixture vigorously stirred. After 6 h the solvents were evaporated, toluene added to the residue and the process repeated. This was done twice more. The residual solid was chromatographed on silica to give the title compound as a white solid (1.17 g), νmax (Nujol) 3440, 3250, 3120, 1720, and 1620 cm-1 ; δH (CDCl3) inter alia 1.35 (3H, t, J 7 Hz), 4.0 (2H, d, J 7 Hz), 4.37 (2H, q, J 7 Hz), 5.4 (2H, broad s, exch. D2O), and 6.67 (1H, s).

後処理

  1. customAfter 6 h the solvents were evaporated
  2. additiontoluene added to the residue
  3. customThe residual solid was chromatographed on silica

出典と根拠

ORDレコード
ord-7952a0d63317461b9b87aa4b7f48ac6e
出典データセット
uspto-grants-1989_03
特許番号
US04816452

反応ノート

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