Hydrochloric Acid → HCID 12300190、化合物

HRID 1195075ノート

反応式

HRID 1195075 の反応式
[OH-].[K+].C[O:4][C:5]([C@@H:7]1[CH:22]=[C:21]2[C@@H:11]([CH2:12][C:13]3[C:23]4[C:16](=[CH:17][CH:18]=[CH:19][C:20]2=4)[NH:15][C:14]=3[Br:24])[N:9]([CH3:10])[CH2:8]1)=[O:6].Cl>C(O)C>[Br:24][C:14]1[NH:15][C:16]2[C:23]3[C:13]=1[CH2:12][C@@H:11]1[C:21]([C:20]=3[CH:19]=[CH:18][CH:17]=2)=[CH:22][C@@H:7]([C:5](=[O:4])[OH:6])[CH2:8][N:9]1[CH3:10]

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 14797Potassium HydroxideHCID 13059865HCID 13059865、化合物

生成物 1

HCID 12300190HCID 12300190、化合物

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

反応条件

温度
80 °C

実験手順

20 ml of 20% aqueous potassium hydroxide solution are added to the solution of 1 g of 2-bromolysergic acid methyl ester in 6 ml of ethanol, then the solution is stirred in a bath of 80° C. for one hour. The pH value of the solution cooled down is adjusted to 7 by adding aqueous hydrochloric acid. The crystalline precipitate obtained on cooling is filtered off, washed with water and dried to give the title compound in a yield of 0.5 g (0.0014 mole, 50%).

後処理

  1. temperatureThe pH value of the solution cooled down
  2. customThe crystalline precipitate obtained
  3. temperatureon cooling
  4. filtrationis filtered off
  5. washwashed with water
  6. customdried

出典と根拠

ORDレコード
ord-a1fd274d04e24daabc96a64d1c3208c1
出典データセット
uspto-grants-1989_03
特許番号
US04816587

反応ノート

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