2-(4-Methoxyphenoxy)ethylamine → 2-{2-Hydroxy-3-[2-(4-methoxyphenoxy)ethylamino]-propoxy}-5-(2-methoxyethoxy)benzonitrile

HRID 1195081ノート

反応式

HRID 1195081 の反応式
[O:1]1[CH2:18][CH:2]1[CH2:3][O:4][C:5]1[CH:12]=[CH:11][C:10]([O:13][CH2:14][CH2:15][O:16][CH3:17])=[CH:9][C:6]=1[C:7]#[N:8].[CH3:19][O:20][C:21]1[CH:30]=[CH:29][C:24]([O:25][CH2:26][CH2:27][NH2:28])=[CH:23][CH:22]=1>C(O)C>[OH:1][CH:2]([CH2:18][NH:28][CH2:27][CH2:26][O:25][C:24]1[CH:29]=[CH:30][C:21]([O:20][CH3:19])=[CH:22][CH:23]=1)[CH2:3][O:4][C:5]1[CH:12]=[CH:11][C:10]([O:13][CH2:14][CH2:15][O:16][CH3:17])=[CH:9][C:6]=1[C:7]#[N:8]

参加物

4

反応物 2

HCID 17977932-(4-Methoxyphenoxy)ethylamineHCID 13313566HCID 13313566、化合物

生成物 1

HCID 133135672-{2-Hydroxy-3-[2-(4-methoxyphenoxy)ethylamino]-propoxy}-5-(2-methoxyethoxy)benzonitrile

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

2.4 g of 2-(2,3-epoxypropoxy)-5-(2-methoxyethoxy)-benzonitrile and 8.35 g of 2-(4-methoxyphenoxy)ethylamine are dissolved in 30 ml of ethanol, the solvent is then evaporated and the resulting mixture stirred for 1 hour at 70°. The reaction melt is then dissolved in ether and allowed to crystallize under cooling. Purification is effected by recrystallization in benzene. The title compound is obtained (M.P. 95°-97°).

後処理

  1. customthe solvent is then evaporated
  2. dissolutionThe reaction melt is then dissolved in ether
  3. customto crystallize
  4. temperatureunder cooling
  5. customPurification
  6. customis effected by recrystallization in benzene

出典と根拠

ORDレコード
ord-472781582779427499382d0354e23d27
出典データセット
uspto-grants-1989_03
特許番号
US04816604

反応ノート

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