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3,3,3-Trifluoropropanal → (4R,9aR)-4-Methyl-6-((RS)-3,3,3-trifluoro-1-hydroxy-propyl)-3,4,9,9a-tetrahydro-1H-2,4a,5-triaza-fluorene-2-carboxylic acid tert-butyl ester
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 3,3,3-Trifluoropropanal | HCID 68028 | — |
| 反応物 | (4R,9aR)-6-(2-hydroxy-ethoxymethyl)-4-methyl-3,4,9,9a-tetrahydro-1H-2,4a,5-triaza-fluorene-2-carboxylic acid tert-butyl ester | HCID 69557393 | — |
| 反応物 | HCID 178418306 | HCID 178418306 | — |
| 生成物 | (4R,9aR)-4-Methyl-6-((RS)-3,3,3-trifluoro-1-hydroxy-propyl)-3,4,9,9a-tetrahydro-1H-2,4a,5-triaza-fluorene-2-carboxylic acid tert-butyl ester | HCID 69556370 | — |
反応手順
This compound was prepared in analogy to Example 38 intermediate, from (4R,9aR)-6-bromo-4-methyl-3,4,9,9a-tetrahydro-1H-2,4a,5-triaza-fluorene-2-carboxylic acid tert-butyl ester (Example 5, intermediate b), tert-butyllithium and 3,3,3-trifluoropropanal.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07098337B2 |
| 出典データセット | uspto-grants-2006_08 |
| ORD ID | ord-e32ff7f058cb4325997af10b7ac9c6ab |
| 出典メモ | uspto-grants-2006_08 |