Hydrochloric Acid → 5-(Chloromethyl)-6-propyl-1,3-benzodioxole

HRID 1195281ノート

反応式

HRID 1195281 の反応式
CCCCOCCOCCO[CH2:12][C:13]1[CH:14]=[C:15]2[O:24][CH2:23][O:22][C:16]2=[CH:17][C:18]=1[CH2:19][CH2:20][CH3:21].[ClH:25].O>C1C=CC=CC=1>[CH2:19]([C:18]1[C:13]([CH2:12][Cl:25])=[CH:14][C:15]2[O:24][CH2:23][O:22][C:16]=2[CH:17]=1)[CH2:20][CH3:21]

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 962WaterHCID 5794Piperonyl Butoxide

生成物 1

HCID 747395-(Chloromethyl)-6-propyl-1,3-benzodioxole

試薬・触媒・溶媒 1

HCID 241Benzene溶媒

実験手順

15 g of piperonyl butoxide and 300 ml of concentrated hydrochloric acid were dissolved in 100 ml of benzene and the solution was heated under reflux for 3 h. The reaction mixture was cooled to room temperature and water was added thereto. After extraction with ethyl acetate, the extract was washed with water, dried over magnesium sulfate and concentrated under reduced pressure to obtain 12 g of 6-propyl-5-chloromethyl-1,3-benzodioxole in the form of a faint brown oil.

後処理

  1. temperaturethe solution was heated
  2. temperatureunder reflux for 3 h
  3. extractionAfter extraction with ethyl acetate
  4. washthe extract was washed with water
  5. dry with materialdried over magnesium sulfate
  6. concentrationconcentrated under reduced pressure

出典と根拠

ORDレコード
ord-1278d1fec602435a80145e076215f150
出典データセット
uspto-grants-1992_05
特許番号
US05110956

反応ノート

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