化工社化工社 化学情報印刷レポート · 研究参考用
3-Methyl-2-butanone → (4R,9aR)-6-(1-(RS)-Hydroxy-1,2-dimethyl-propyl)-4-methyl-3,4,9,9a-tetrahydro-1H-2,4a,5-triaza-fluorene-2-carboxylic acid tert-butyl ester
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 3-Methyl-2-butanone | HCID 11251 | — |
| 反応物 | (4R,9aR)-6-(2-hydroxy-ethoxymethyl)-4-methyl-3,4,9,9a-tetrahydro-1H-2,4a,5-triaza-fluorene-2-carboxylic acid tert-butyl ester | HCID 69557393 | — |
| 反応物 | Butyllithium | HCID 178418339 | — |
| 生成物 | (4R,9aR)-6-(1-(RS)-Hydroxy-1,2-dimethyl-propyl)-4-methyl-3,4,9,9a-tetrahydro-1H-2,4a,5-triaza-fluorene-2-carboxylic acid tert-butyl ester | HCID 69556836 | — |
反応手順
This compound was prepared in analogy to Example 51 intermediate, from (4R,9aR)-6-bromo-4-methyl-3,4,9,9a-tetrahydro-1H-2,4a,5-triaza-fluorene-2-carboxylic acid tert-butyl ester (Example 5, intermediate b), n-butyllithium and 3-methyl-2-butanone.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07098337B2 |
| 出典データセット | uspto-grants-2006_08 |
| ORD ID | ord-1b6e5e145c19478197b39aa10504cac1 |
| 出典メモ | uspto-grants-2006_08 |