Potassium Carbonate → HCID 57226673、化合物

反応式

[CH3:1][NH:2][CH2:3][C:4]1[CH:9]=[CH:8][C:7]([C:10]([CH3:13])([CH3:12])[CH3:11])=[CH:6][CH:5]=1.C(=O)([O-])[O-].[K+].[K+].[F:20][C:21]1[CH:30]=[C:29]([F:31])[CH:28]=[C:27]2[C:22]=1[CH:23]=[CH:24][CH:25]=[C:26]2[CH2:32]Br>CN(C)C=O>[F:20][C:21]1[CH:30]=[C:29]([F:31])[CH:28]=[C:27]2[C:22]=1[CH:23]=[CH:24][CH:25]=[C:26]2[CH2:32][N:2]([CH2:3][C:4]1[CH:9]=[CH:8][C:7]([C:10]([CH3:13])([CH3:12])[CH3:11])=[CH:6][CH:5]=1)[CH3:1]

参加物

実験手順

To a mixture of 0.3 g of N-methyl-4-tert.butylbenzylamine, 0.25 g of potassium carbonate and 5 ml of abs. dimethylformamide (DMF) are added dropwise 0.4 g of 5,7-difluoro-1-bromomethylnaphthalene and the mixture stirred overnight at RT. The solvent is removed under vacuum and the residue partitioned between ether and water. The organic phase is dried and evaporated. The pure product is obtained as an oil following chromatography on silica gel (eluant: hexane/ethylacetate=95/5).