Hydrochloric Acid → Methyl L-lysinate dihydrochloride

HRID 1196151

反応式

HRID 1196151 の反応式
N[C@H:2](C(O)=O)CC1C=CC=CC=1.[ClH:13].[NH2:14][C@H:15]([C:21]([OH:23])=[O:22])[CH2:16][CH2:17][CH2:18][CH2:19][NH2:20].Cl>CO>[ClH:13].[ClH:13].[CH3:2][O:22][C:21](=[O:23])[C@H:15]([CH2:16][CH2:17][CH2:18][CH2:19][NH2:20])[NH2:14]

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 6140L-PhenylalanineHCID 69568L-Lysine monohydrochloride

生成物 1

HCID 117778Methyl L-lysinate dihydrochloride収率 81.3%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

The same esterification procedure as in Example 1 was followed with the exception that the L-phenylalanine was replaced with 182.6 g of L-lysine hydrochloride and that 182.6 g of methanol and 87.3 g of hydrochloric acid were used. Following cooling in order to deposit the crystals, the latter were collected by filtration and then dried to obtain 196.2 g (81.3% yield) of L-lysine methyl ester dihydrochloride having a purity of 96.6% and containing 0.2% of water and 1.3% of L-lysine hydrochloride.

後処理

  1. temperatureFollowing cooling in order
  2. filtrationthe latter were collected by filtration
  3. customdried

出典と根拠

ORDレコード
ord-a684a2a53a82466280c15e3ac7fb6c5f
出典データセット
uspto-grants-1992_05
特許番号
US05113009

関連ノート

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