Benzylamine → HCID 12435486、化合物
反応式
[CH2:1]([O:3][CH:4]([O:8][CH2:9][CH3:10])[C:5](Cl)=[O:6])[CH3:2].[CH2:11]([NH2:18])[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1>>[CH2:11]([NH:18][C:5](=[O:6])[CH:4]([O:8][CH2:9][CH3:10])[O:3][CH2:1][CH3:2])[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1参加物
3
実験手順
Ethyl diethoxyacetate (Ex. Fluka) (25 g) was added to sodium hydroxide (5.68 g) in ethanol (60 ml) and water (30 ml). After heating under reflux for 5 hours the solvents were removed at reduced pressure and the residue dried in vacuo to give sodium diethoxyacetate (23.2 g). The salt was then converted to diethoxyacetyl chloride and reacted with benzylamine to give N-benzyl diethoxyacetamide which was cyclised with conc. sulphuric acid according to Fukumi and Hideshi, Heterocycles, 9, 1197 (1978) to give 3-hydroxyisoquinoline.
出典と根拠
- ORDレコード
- ord-1010de09e3ab4a09a58e340b0c33b324
- 出典データセット
- uspto-grants-1992_05
- 特許番号
- US05114940
反応ノート
読み込み中…