4-(4-Trifluoromethylbenzyloxy)-2-chloromethylpyridine → 2-[4-(4-Trifluoromethylbenzyloxy)-2-picolylmercapto]-1H-thieno[3,4-d]imidazole dihydrochloride

HRID 1196624ノート

反応式

HRID 1196624 の反応式
[SH:1][C:2]1[NH:3][C:4]2[C:5](=[CH:7][S:8][CH:9]=2)[N:6]=1.[F:10][C:11]([F:29])([F:28])[C:12]1[CH:27]=[CH:26][C:15]([CH2:16][O:17][C:18]2[CH:23]=[CH:22][N:21]=[C:20]([CH2:24][Cl:25])[CH:19]=2)=[CH:14][CH:13]=1>C(O)C>[ClH:25].[ClH:25].[F:29][C:11]([F:10])([F:28])[C:12]1[CH:27]=[CH:26][C:15]([CH2:16][O:17][C:18]2[CH:23]=[CH:22][N:21]=[C:20]([CH2:24][S:1][C:2]3[NH:6][C:5]4=[CH:7][S:8][CH:9]=[C:4]4[N:3]=3)[CH:19]=2)=[CH:14][CH:13]=1

参加物

4

反応物 2

HCID 144259864-(4-Trifluoromethylbenzyloxy)-2-chloromethylpyridineHCID 178527818HCID 178527818、化合物

生成物 1

HCID 198989772-[4-(4-Trifluoromethylbenzyloxy)-2-picolylmercapto]-1H-thieno[3,4-d]imidazole dihydrochloride

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

反応条件

温度
60 °C

実験手順

0.625 g (4 mmol) of 2-mercaptothieno[3,4-d]imidazole are added at 25° C. to 1.35 g (4 mmol) of the title compound from Example 4 in 50 ml of ethanol, and the mixture is stirred at 60° C. for 1.5 hours. The reaction mixture is concentrated in vacuo, and the residue is treated with acetone, filtered off with suction, washed with acetone and dried in vacuo, m.p. 180°-182° C.

後処理

  1. concentrationThe reaction mixture is concentrated in vacuo
  2. additionthe residue is treated with acetone
  3. filtrationfiltered off with suction
  4. washwashed with acetone
  5. customdried in vacuo, m.p. 180°-182° C.

出典と根拠

ORDレコード
ord-b3d8160494eb43e98587a971b3517321
出典データセット
uspto-grants-1992_05
特許番号
US05114955

反応ノート

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