2,2,3,3-Tetrafluoro-1-propanol → 2,2,3,3-Tetrafluoropropyl 4-toluenesulfonate

HRID 1196788

反応式

HRID 1196788 の反応式
C(Cl)(F)C(F)(F)C(Cl)(F)F.[F:11][C:12]([F:18])([CH:15]([F:17])[F:16])[CH2:13][OH:14].[S:19](Cl)([C:22]1[CH:28]=[CH:27][C:25]([CH3:26])=[CH:24][CH:23]=1)(=[O:21])=[O:20]>O>[C:25]1([CH3:26])[CH:27]=[CH:28][C:22]([S:19]([O:14][CH2:13][C:12]([F:18])([F:11])[CH:15]([F:17])[F:16])(=[O:21])=[O:20])=[CH:23][CH:24]=1

参加物

5

反応物 3

HCID 64412,2,3,3-Tetrafluoro-1-propanolHCID 73974-Toluenesulfonyl chlorideHCID 623531,3-Dichloro-1,1,2,2,3-pentafluoropropane3 回

生成物 1

HCID 20605972,2,3,3-Tetrafluoropropyl 4-toluenesulfonate

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

Until HCFC-225cb becomes available in commercial quantities, HCFC-225cb may be prepared by a standard and well-known organic systhesis technique. For example, to prepare 1,3-dichloro-1,1,2,2,3-pentafluoropropane, 2,2,3,3-tetrafluoropropanol, tosyl chloride, and water are reacted together to form 2,2,3,3-tetrafluoropropyl p-toluenesulfonate. Then, N-methylpyrrolidone, potassium fluoride, and the 2,2,3,3-tetrafluoropropyl p-toluenesulfonate are reacted together to form 1,1,2,2,3-pentafluoropropane. Then, chlorine and the 1,1,2,2,3-pentafluoropropane are reacted to form 1,1,3-trichloro-1,2,2,3,2-pentafluoropropane. Finally, isopropanol and the 1,1,3-trichloro-1,2,2,3,2-pentafluoropropane are reacted to form 1,3-dichloro-1,1,2,2,3-pentafluoropropane. A detailed synthesis is set forth below.

後処理

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出典と根拠

ORDレコード
ord-c53a1b19b3b7496c911e39d906d31257
出典データセット
uspto-grants-1992_05
特許番号
US05116526

関連ノート

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