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Hydrochloric Acid → HCID 15024388、化合物
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | Glycylglycine | HCID 11163 | — |
| 反応物 | N-[(Phenylmethoxy)carbonyl]-L-tyrosine methyl ester | HCID 7010613 | — |
| 溶媒 | Dimethyl Sulfoxide | HCID 679 | — |
| 生成物 | HCID 15024388 | HCID 15024388 | — |
反応手順
330 mg (1 mmole) of Z-L-Tyr-OMe, 400 mg (2.2 mmole) of H-Gly-Gly-Ome, HCl were suspended in 5 mL DMSO and 5 mL 0.1 M tris-HCl, pH 8.9. 25 mg of α-chymotrypsin were added and the reaction stirred for 30 minutes. Five volumes of ice water were added, and the precipitate collected by filtration. Yield 312 mg (70%, based on acyl-donor). Amino acid analysis: tyr1.0,gly2.1.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05116741 |
| 出典データセット | uspto-grants-1992_05 |
| ORD ID | ord-3045a12175474c26a96874021fff6f5d |
| 出典メモ | uspto-grants-1992_05 |