[CH:1]([NH:3][C@H:4]([C:9]([OH:11])=O)[CH2:5][CH2:6][S:7][CH3:8])=[O:2].[F:12][C@:13]12[C@@H:33]([OH:34])[CH2:32][C@@:31]3([CH3:35])[C@@H:23]([CH2:24][C@H:25]([CH3:37])[C@:26]3([OH:36])[C:27](=[O:30])[CH2:28][SH:29])[C@@H:22]1[CH2:21][CH2:20][C:19]1[C@:14]2([CH3:39])[CH:15]=[CH:16][C:17](=[O:38])[CH:18]=1.C1(N=C=NC2CCCCC2)CCCCC1>C(OCC)(=O)C>[F:12][C@:13]12[C@@H:33]([OH:34])[CH2:32][C@@:31]3([CH3:35])[C@@H:23]([CH2:24][C@H:25]([CH3:37])[C@:26]3([OH:36])[C:27](=[O:30])[CH2:28][S:29][C:9](=[O:11])[CH:4]([NH:3][CH:1]=[O:2])[CH2:5][CH2:6][S:7][CH3:8])[C@@H:22]1[CH2:21][CH2:20][C:19]1[C@:14]2([CH3:39])[CH:15]=[CH:16][C:17](=[O:38])[CH:18]=1To a stirred solution of of N-formyl-L-methionine (7.8 gm) in dry ethyl acetate (120 ml) were added 9-fluoro-11β,17-dihydroxy-16β-methylpregna-1,4-diene-3,20-dione-21-thiol (6.0 gm) in dry ethyl acetate (100 ml) and dicyclohexylcarbodiimide (18.2 gm) in dry ethyl acetate (100 ml) at room temperature. The reaction mixture was stirred at room temperature for for 4 hours.
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