Dimethylamine → (3-(Dimethylamino)propyl)triphenylphosphonium bromide hydrobromide

HRID 1196987ノート

反応式

HRID 1196987 の反応式
[BrH:1].[Br-].[Br:3][CH2:4][CH2:5][CH2:6][P+:7]([C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1)([C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1)[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1.[CH3:26][NH:27][CH3:28]>C(O)C>[BrH:3].[Br-:1].[CH3:26][N:27]([CH3:28])[CH2:4][CH2:5][CH2:6][P+:7]([C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1)([C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1)[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1

参加物

4

反応物 2

HCID 674DimethylamineHCID 19897085(3-Bromopropyl)-triphenylphosphonium bromide hydrobromide

生成物 1

HCID 23651404(3-(Dimethylamino)propyl)triphenylphosphonium bromide hydrobromide

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

Then, 100.0 g of (3-bromopropyl)-triphenylphosphonium bromide hydrobromide is suspended in 500 ml of ethanol and 300 ml of 50% aqueous dimethylamine solution is added thereto. After heating the mixture at reflux for 10 minutes, the mixture is allowed to stand for cooling. The solvent is distilled away under reduced pressure and the resultant crude product is recrystallized from ethanol to obtain 64.0 g of the desired product having the physicochemical properties as identified in Table 8.

後処理

  1. temperatureAfter heating the mixture
  2. temperatureat reflux for 10 minutes
  3. temperaturefor cooling
  4. distillationThe solvent is distilled away under reduced pressure
  5. customthe resultant crude product is recrystallized from ethanol

出典と根拠

ORDレコード
ord-a8437e3468174024ae8d418037873a05
出典データセット
uspto-grants-1992_05
特許番号
US05116863

反応ノート

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