Acetic Anhydride → 2,6-dimethyl-4H-3,1-benzoxazin-4-one

HRID 1197117ノート

反応式

HRID 1197117 の反応式
[CH3:1][C:2]1[CH:10]=[C:6]([C:7]([OH:9])=[O:8])[C:5]([NH2:11])=[CH:4][CH:3]=1.[C:12](OC(=O)C)(=O)[CH3:13]>>[CH3:12][C:13]1[O:8][C:7](=[O:9])[C:6]2[CH:10]=[C:2]([CH3:1])[CH:3]=[CH:4][C:5]=2[N:11]=1

参加物

3

反応物 2

HCID 7918Acetic AnhydrideHCID 762552-Amino-5-methylbenzoic acid

生成物 1

HCID 27965282,6-dimethyl-4H-3,1-benzoxazin-4-one

実験手順

45.5 g (0.3 mol) of 5-Methylanthranilic acid are refluxed together with 130 g of acetic anhydride for 3 hours. After the solvent has been evaporated in vacuo, the residue is dissolved in 200 ml of dichloromethane, and the solution is filtered through silica gel. The concentrated filtrate is induced to crystallise with isopropyl ether.

後処理

  1. customAfter the solvent has been evaporated in vacuo
  2. dissolutionthe residue is dissolved in 200 ml of dichloromethane
  3. filtrationthe solution is filtered through silica gel
  4. customto crystallise with isopropyl ether

出典と根拠

ORDレコード
ord-870075bdc07e436cbec7a3fd48b81d16
出典データセット
uspto-grants-1992_05
特許番号
US05116971

反応ノート

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