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2,5-Hexanedione → Ethyl 5,8-dimethylcarbazole-4-carboxylate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2,5-Hexanedione | HCID 8035 | — |
| 反応物 | p-Toluenesulfonic acid monohydrate | HCID 521998 | — |
| 反応物 | Ethyl indole-4-carboxylate | HCID 605034 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | Ethyl 5,8-dimethylcarbazole-4-carboxylate | HCID 19897884 | 39.8% |
反応手順
A mixture of 13.24 g of ethyl indole-4-carboxylate, 15.98 g of acetonylacetone and 13.31 g of p-toluenesulfonic acid monohydrate in 50 ml of ethanol was refluxed for 10 hours. The ethanol was evaporated under reduced pressure, the residue was chromatographed on silica gel column with hexane - ethyl acetate (9 : 1) to give 7.45 g of ethyl 5,8-dimethylcarbazole-4-carboxylate.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05116995 |
| 出典データセット | uspto-grants-1992_05 |
| ORD ID | ord-7011647797124f60ab76be0535658e02 |
| 出典メモ | uspto-grants-1992_05 |