Water → 2-Hydroxymethyl-2-n-propyl propan-1,3-diol trimethanesulphonate

関与物質

反応手順

Methanesulphonyl chloride (74.0 g) was added dropwise over 30 minutes to a solution of 2-hydroxymethyl-2-n-propylpropan-1,3-diol (28.0 g) in dry pyridine (200 ml) under nitrogen at 0° C. The mixture was allowed to warm to room temperature. After stirring for 18 hours the mixture was poured into water (200 ml) and extracted with chloroform (2×200 ml). The chloroform extracts were washed with water (2×100 ml), dried over anhydrous magnesium sulphate and evaporated in vacuo to give a brown solid. This was stirred in dry diethyl ether (200 ml) to give 2-hydroxymethyl-2-n-propylpropan-1,3-diol trimethanesulphonate as a white solid. (70.0 g)(m.pt. 103.6°).

情報源と証拠