化工社化工社 化学情報印刷レポート · 研究参考用
Dimethyl Sulfoxide → [(4-Ethenylphenyl)methyl](methyl)propanedinitrile
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Dimethyl Sulfoxide | HCID 679 | — |
| 反応物 | Triethylamine | HCID 8471 | — |
| 反応物 | p-Vinylbenzyl chloride | HCID 74126 | — |
| 反応物 | Propanedinitrile,2-methyl- | HCID 57349445 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | [(4-Ethenylphenyl)methyl](methyl)propanedinitrile | HCID 71402933 | 64% |
反応手順
A sample (2.53 g) of triethylamine (25 mmol) was added dropwise to a mixture of 4.01 g 4-vinylbenzyl chloride (25 mmol), 2.00 g monomethyl malonitrile (25 mmol), and 15 mL DMSO at room temperature. The mixture was stirred at room temperature for 17 hours then poured into 100 mL water. A pink solid precipitated and was filtered. The solid was recrystallized from a mixture of methanol and water to give 3.141 g (64%) of pinkish crystals.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07098525B2 |
| 出典データセット | uspto-grants-2006_08 |
| ORD ID | ord-ca7f67dfd1304f62a578fc6a4b55c45f |
| 出典メモ | uspto-grants-2006_08 |