2-Propanethiol, 1-amino-, hydrochloride → HCID 19106459、化合物

反応式

Cl[C:2]1([S:12]([NH2:15])(=[O:14])=[O:13])[CH:6](C(OCC)=O)[CH:5]=[CH:4][S:3]1.Cl.[NH2:17][CH2:18][CH:19]([SH:21])[CH3:20].[O-:22][CH2:23]C.[Na+]>>[CH3:20][CH:19]1[CH2:18][NH:17][C:23](=[O:22])[C:5]2[CH:6]=[C:2]([S:12](=[O:13])(=[O:14])[NH2:15])[S:3][C:4]=2[S:21]1

参加物

反応物 3

HCID 1457272-Propanethiol, 1-amino-, hydrochloride

HCID 2723922Sodium ethoxide

HCID 19106453HCID 19106453、化合物

生成物 1

HCID 19106459HCID 19106459、化合物収率 51%

実験手順

Following the procedure described in Example 1, Step E, 2-chloro-3-carboethoxythiophene-2-sulfonamide was reacted with 1-amino-2-propanethiol hydrochloride in the presence of four equivalents of sodium ethoxide to give, after recrystallization from ethyl acetate, a 51% yield of title compound, mp 199°-201° C.