N-Methylaniline → 2-Chloro-4-(N-methylphenylamino)thieno[2,3-d]pyrimidine

HRID 1198113ノート

反応式

HRID 1198113 の反応式
[Cl:1][C:2]1[N:3]=[C:4](Cl)[C:5]2[CH:10]=[CH:9][S:8][C:6]=2[N:7]=1.[CH3:12][NH:13][C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1>C(O)C>[Cl:1][C:2]1[N:3]=[C:4]([N:13]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[CH3:12])[C:5]2[CH:10]=[CH:9][S:8][C:6]=2[N:7]=1

参加物

4

反応物 2

HCID 7515N-MethylanilineHCID 122173242,4-Dichlorothieno[2,3-d]pyrimidine

生成物 1

HCID 103560572-Chloro-4-(N-methylphenylamino)thieno[2,3-d]pyrimidine

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

2,4-Dichlorothieno[2,3-d]pyrimidine (4.5 g, 0.022 mol) and N-methylaniline (4.7 g, 0.044 mol) in ethanol (50 ml) were stirred at room temperature for 72 hours. The solid obtained was collected by filtration, washed with ethanol and dried, 5.15 g. Recrystallization from ethyl acetate gave the title compound, m.p. 167°-168°.

後処理

  1. customThe solid obtained
  2. filtrationwas collected by filtration
  3. washwashed with ethanol
  4. customdried
  5. customRecrystallization from ethyl acetate

出典と根拠

ORDレコード
ord-5033a70d127f425d83e1f8f3beeda801
出典データセット
uspto-grants-1994_01
特許番号
US05280026

反応ノート

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