Water → 4-Acetyl-1-benzylpyrrolidin-2-one

HRID 1198608ノート

反応式

HRID 1198608 の反応式
[CH2:1]([N:8]1[CH2:12][CH:11]([C:13](=[O:18])[CH2:14]C([O-])=O)[CH2:10][C:9]1=[O:19])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[Cl-].[Na+].O>CS(C)=O>[C:13]([CH:11]1[CH2:12][N:8]([CH2:1][C:2]2[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=2)[C:9](=[O:19])[CH2:10]1)(=[O:18])[CH3:14]

参加物

5

反応物 3

HCID 962WaterHCID 5234Sodium ChlorideHCID 19102755HCID 19102755、化合物

生成物 1

HCID 100820724-Acetyl-1-benzylpyrrolidin-2-one収率 83.2%

試薬・触媒・溶媒 1

HCID 679Dimethyl Sulfoxide溶媒

実験手順

A mixture of 3-(1-benzyl-2-oxopyrrolidin-4-yl)-3-oxopropanoate (24.0 g, 0.083 mole) and sodium chloride (10.6 g, 0.181 mole) in dimethylsulfoxide (105 mL)/water (4.4 mL) was heated at 135° with stirring for 16 hours. On cooling the reaction mixture was poured onto ice water (900 mL) and extracted with dichloromethane (800 mL). The organic phase was washed with water (4×500 mL) and dried (MgSO4). The solvent was removed under reduced pressure to give 4-acetyl-1-benzyl-2-pyrrolidinone (15.0 g, 83%) as a brown oil.

後処理

  1. temperaturewas heated at 135°
  2. temperatureOn cooling the reaction mixture
  3. additionwas poured onto ice water (900 mL)
  4. extractionextracted with dichloromethane (800 mL)
  5. washThe organic phase was washed with water (4×500 mL)
  6. dry with materialdried (MgSO4)
  7. customThe solvent was removed under reduced pressure

出典と根拠

ORDレコード
ord-fb770d900b0e4b18ad802b5fc0f1a253
出典データセット
uspto-grants-1994_01
特許番号
US05281612

反応ノート

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