HCID 85126173、化合物 → HCID 15223491、化合物

HRID 1198610ノート

反応式

HRID 1198610 の反応式
[CH2:1]([N:8]1[CH2:12][CH:11]([C:13](=[N:15]O)[CH3:14])[CH2:10][C:9]1=[O:17])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1>N.[Ni]>[NH2:15][CH:13]([CH:11]1[CH2:12][N:8]([CH2:1][C:2]2[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=2)[C:9](=[O:17])[CH2:10]1)[CH3:14]

参加物

4

反応物 1

HCID 85126173HCID 85126173、化合物

生成物 1

HCID 15223491HCID 15223491、化合物収率 91.6%

試薬・触媒・溶媒 2

HCID 935Nickel触媒2 回HCID 222Ammonia溶媒

実験手順

1-Benzyl-4-(1-hydroxyiminoethyl)-2-oxopyrrolidine (16.81 g, 0.072 mole), was hydrogenated in saturated methanolic ammonia (200 mL) at 50 psi and 25° with Raney nickel (5 g) for 23 hours. Additional Raney nickel (5 g) was added and hydrogenation continued for three hours. The reaction was Celite filtered and the solvent was removed under reduced pressure to give 4-(1-aminoethyl)-1-benzyl-2-oxopyrrolidine (14.4 g, 91%) as a brown oil which solidified on standing to a brown solid.

後処理

  1. filtrationfiltered
  2. customthe solvent was removed under reduced pressure

出典と根拠

ORDレコード
ord-f4031b5520b943d0a7d15cfddfdef667
出典データセット
uspto-grants-1994_01
特許番号
US05281612

反応ノート

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