Tert-Butylamine → N-tert-butyl-4-propylbenzenesulfonamide

HRID 1198673

反応式

HRID 1198673 の反応式
[CH2:1]([C:4]1[CH:9]=[CH:8][C:7]([S:10](Cl)(=[O:12])=[O:11])=[CH:6][CH:5]=1)[CH2:2][CH3:3].[C:14]([NH2:18])([CH3:17])([CH3:16])[CH3:15]>C(Cl)Cl>[C:14]([NH:18][S:10]([C:7]1[CH:8]=[CH:9][C:4]([CH2:1][CH2:2][CH3:3])=[CH:5][CH:6]=1)(=[O:12])=[O:11])([CH3:17])([CH3:16])[CH3:15]

参加物

4

反応物 2

HCID 6385Tert-ButylamineHCID 27372224-N-Propylbenzenesulphonyl chloride

生成物 1

HCID 6470063N-tert-butyl-4-propylbenzenesulfonamide

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

To a solution of 4-n-propylbenzenesulfonyl chloride (Lancaster) in anhydrous CH2Cl2 (0.5M solution) cooled to 0° C. under N2 was added t-butylamine (2.2 equiv) slowly through a dropping funnel. After complete addition, the reaction was stirred at room temperature for 12 hours. The CH2Cl2 was removed under reduced pressure, and the residue was extracted into ether and washed with 2N NaOH, H2O and brine. The organic phase was dried over anhydrous MgSO4 and concentrated in vacuo to afford the titled product; Rf =0.46 (3:1 hexane-EtOAc).

後処理

  1. additionAfter complete addition
  2. customThe CH2Cl2 was removed under reduced pressure
  3. extractionthe residue was extracted into ether
  4. washwashed with 2N NaOH, H2O and brine
  5. dry with materialThe organic phase was dried over anhydrous MgSO4
  6. concentrationconcentrated in vacuo

出典と根拠

ORDレコード
ord-4baec7ebc0bb47e2930d93cda17f657e
出典データセット
uspto-grants-1994_01
特許番号
US05281614

関連ノート

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