Methanol → 5-n-Butyl-2-[2-chloro-5-(methoxycarbonyl)phenyl]-2,4-dihydro-3H-1,2,4-triazol-3-one

HRID 1198684

反応式

HRID 1198684 の反応式
[Cl:1][C:2]1[CH:11]=[CH:10][C:5]([C:6]([O:8][CH3:9])=[O:7])=[CH:4][C:3]=1[NH:12][NH2:13].C(Cl)Cl.[CH3:17][OH:18]>>[CH2:2]([C:3]1[NH:12][C:17](=[O:18])[N:12]([C:3]2[CH:4]=[C:5]([C:6]([O:8][CH3:9])=[O:7])[CH:10]=[CH:11][C:2]=2[Cl:1])[N:13]=1)[CH2:11][CH2:10][CH3:5]

参加物

4

反応物 3

HCID 887MethanolHCID 6344DichloromethaneHCID 292358Methyl 4-chloro-3-hydrazinylbenzoate

生成物 1

HCID 1357200825-n-Butyl-2-[2-chloro-5-(methoxycarbonyl)phenyl]-2,4-dihydro-3H-1,2,4-triazol-3-one収率 37%

実験手順

By the procedure of Example 3, Step C, the title compound was prepared from methyl 4-chloro-3-hydrazinobenzoate (from Step B) in 37% yield as an orange gum (TLC in 95:5 CH2Cl2 --MeOH), mass spectrum (FAB) m/e 310 (M+1)+.

出典と根拠

ORDレコード
ord-da3c2a1361b444c783657810b0278f41
出典データセット
uspto-grants-1994_01
特許番号
US05281614

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