Phosphorus pentachloride → (4-Nitrophthalimido)acetyl chloride
反応式
[N+:1]([C:4]1[CH:5]=[C:6]2[C:11](=[O:12])[N:10]([CH2:13][C:14](O)=[O:15])[C:8](=[O:9])[C:7]2=[CH:17][CH:18]=1)([O-:3])=[O:2].P(Cl)(Cl)(Cl)(Cl)[Cl:20]>C1(C)C=CC=CC=1>[N+:1]([C:4]1[CH:5]=[C:6]2[C:11](=[O:12])[N:10]([CH2:13][C:14]([Cl:20])=[O:15])[C:8](=[O:9])[C:7]2=[CH:17][CH:18]=1)([O-:3])=[O:2]参加物
4
実験手順
To a suspension of 2-(4-nitrophthalimido)acetic acid (58.6 g) in toluene (250 ml) was added phosphorus pentachloride (48.8 g) and the mixture was refluxed for 3 hours. After completion of the reaction, the solvent was removed under reduced pressure. By addition of hexane to the residue, the title compound (62.3 g) was obtained as light yellow sharp-pointed needles.
後処理
- temperaturethe mixture was refluxed for 3 hours
- customAfter completion of the reaction
- customthe solvent was removed under reduced pressure
- additionBy addition of hexane to the residue
出典と根拠
- ORDレコード
- ord-c117ea93444b4ec7b7aa2202c7d355e7
- 出典データセット
- uspto-grants-1990_02
- 特許番号
- US04898859
反応ノート
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