化工社化工社 化学情報印刷レポート · 研究参考用
Dimethylformamide → [2-(7-bromo-1,8-naphthyridin-2-yl)-3-oxo-1-isoindolinyl]-N-propylglycolamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Dimethylformamide | HCID 6228 | — |
| 反応物 | Sodium hydride | HCID 24758 | — |
| 反応物 | 2-chloro-N-propylacetamide | HCID 222357 | — |
| 反応物 | 2-(7-Bromo-1,8-naphthyridin-2-yl)-3-hydroxy-1-isoindolinone | HCID 19900421 | — |
| 生成物 | [2-(7-bromo-1,8-naphthyridin-2-yl)-3-oxo-1-isoindolinyl]-N-propylglycolamide | HCID 19867687 | — |
反応手順
The procedure is as in Example 26, but starting with 2-(7-bromo-1,8-naphthyridin-2-yl)-3-hydroxy-1-isoindolinone (12 g) in anhydrous dimethylformamide (300 cc), an oily suspension (50% by weight; 2.4 g) of sodium hydride and N-(propyl)chloroacetamide (6.9 g). After recrystallization in acetonitrile, [2-(7-bromo-1,8-naphthyridin-2-yl)-3-oxo-1-isoindolinyl]-N-propylglycolamide (2.1 g), m.p. 174° C., is obtained.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04898871 |
| 出典データセット | uspto-grants-1990_02 |
| ORD ID | ord-d4f985c2d61648a1ab96336c24aeb34f |
| 出典メモ | uspto-grants-1990_02 |