Potassium Carbonate → 5,6-Dimethoxy-2-(5-methoxy-2-nitrophenylthio)-1H-benzimidazole

HRID 1199460ノート

反応式

HRID 1199460 の反応式
[CH3:1][O:2][C:3]1[C:12]([O:13][CH3:14])=[CH:11][C:6]2=[N:7][C:8](=[S:10])[N:9]=[C:5]2[CH:4]=1.Cl[C:16]1[CH:21]=[C:20]([O:22][CH3:23])[CH:19]=[CH:18][C:17]=1[N+:24]([O-:26])=[O:25].C(=O)([O-])[O-].[K+].[K+]>CN(C)C=O>[CH3:1][O:2][C:3]1[C:12]([O:13][CH3:14])=[CH:11][C:6]2[NH:7][C:8]([S:10][C:16]3[CH:21]=[C:20]([O:22][CH3:23])[CH:19]=[CH:18][C:17]=3[N+:24]([O-:26])=[O:25])=[N:9][C:5]=2[CH:4]=1

参加物

5

反応物 3

HCID 11430Potassium CarbonateHCID 5937892-Chloro-4-methoxy-1-nitrobenzeneHCID 149735355,6-Dimethoxy benzimidazole-2-thione

生成物 1

HCID 198667335,6-Dimethoxy-2-(5-methoxy-2-nitrophenylthio)-1H-benzimidazole

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

5,6-Dimethoxy benzimidazole-2-thione (4.0 g), 2-chloro-4-methoxy nitrobenzene (3.6 g) and potassium carbonate (2.65 g) were stirred together in dry dimethyl formamide (30 ml) at 95° for 3 days. The cooled mixture was poured onto water (300 ml) and the precipitate collected. The solid was washed with water and dried to leave the sub-title compound as a pale yellow solid, MS 361 bp 207.

後処理

  1. additionThe cooled mixture was poured onto water (300 ml)
  2. customthe precipitate collected
  3. washThe solid was washed with water
  4. customdried

出典と根拠

ORDレコード
ord-474972a81f87497380aaf001ea0a06c6
出典データセット
uspto-grants-1990_02
特許番号
US04900751

反応ノート

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