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Nicotinic Acid → N-Nicotinoyltyrosine ethyl ester
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Nicotinic Acid | HCID 938 | — |
| 反応物 | Dicyclohexylcarbodiimide | HCID 10868 | — |
| 反応物 | Tyrosine ethyl ester hydrochloride | HCID 2724939 | — |
| 溶媒 | Pyridine | HCID 1049 | — |
| 生成物 | N-Nicotinoyltyrosine ethyl ester | HCID 53849020 | — |
反応手順
Nicotinic acid (12.3 g, 0.1 mol) was dissolved in dry pyridine (300 ml). The solution was cooled and dicyclohexylcarbodiimide (20.6 g, 0.1 mol) was added. After dissolution, tyrosine ethyl ester hydrochloride (24.6 g, 0.1 mol) was added and the solution was stirred overnight. The precipitated dicyclohexylurea (DCU) was removed by filtration. Additional DCU was removed by triturating the oil with hot water. The product was purified with acetone. Calculated for C17H18N2O4.1/2H2O: C, 63.16; H, 5.88; N, 8.66. Found; C, 63.10; H, 5.96; N, 8.59. The product can also be named N-[1-ethoxycarbonyl-2-(4'-hydroxyphenyl)ethyl]nicotinamide.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04900837 |
| 出典データセット | uspto-grants-1990_02 |
| ORD ID | ord-2bd1f584ec8147c08aead3d64ebae227 |
| 出典メモ | uspto-grants-1990_02 |