Potassium Carbonate → Benzene, 1-chloro-4-ethynyl-
反応式
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]#[C:9][Si](C)(C)C)=[CH:4][CH:3]=1.C(=O)([O-])[O-].[K+].[K+]>CO.CCCCCC>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]#[CH:9])=[CH:4][CH:3]=1参加物
5
実験手順
To a solution of 2(4-chlorophenyl)-1-trimethylsilylethyne Prepared in Stage 1 (30.90g:0.02 mole) in methanol was added potassium carbonate (0.276g:002 mole). The mixture was stirred at room temperature until starting material disappeared as monitored by gas liquid chromatography. After this time, solvent was removed in vacuo and the residue taken up in dichloromethane. The solution was dried and declourised over charcoal. Filtration, followed by removal of solvent gave a brown solid which was passed through silica in hexane. This gave pale yellow crystals (1.511g:55.3%)
後処理
- customAfter this time, solvent was removed in vacuo
- customThe solution was dried
- filtrationFiltration
- customfollowed by removal of solvent
- customgave a brown solid which
出典と根拠
- ORDレコード
- ord-04cdcb925b3b4ffb92883ea9d746ec49
- 出典データセット
- uspto-grants-1990_02
- 特許番号
- US04902332
反応ノート
読み込み中…