ホームMCPワークベンチSkills
ホームワークベンチ通知マイページ
llms.txt · MCPガイドプライバシーポリシー · 利用規約 · サポートv1.8.0
  1. ホーム
  2. /反応

Potassium Hydroxide → 2-[trans-3-(3-Carboxy-3,3-dimethylpropyloxy)styryl]-4-isopropylthiazole

HRID 1199712
ノート
印刷プレビュー

反応式

HRID 1199712 の反応式
[CH3:1][C:2]([CH3:27])([C:22]([O:24]CC)=[O:23])[CH2:3][CH2:4][O:5][C:6]1[CH:7]=[C:8]([CH:19]=[CH:20][CH:21]=1)/[CH:9]=[CH:10]/[C:11]1[S:12][CH:13]=[C:14]([CH:16]([CH3:18])[CH3:17])[N:15]=1.[OH-].[K+]>C(O)C.CO.[OH-].C([N+](C)(C)C)C1C=CC=CC=1>[C:22]([C:2]([CH3:27])([CH3:1])[CH2:3][CH2:4][O:5][C:6]1[CH:7]=[C:8]([CH:19]=[CH:20][CH:21]=1)/[CH:9]=[CH:10]/[C:11]1[S:12][CH:13]=[C:14]([CH:16]([CH3:17])[CH3:18])[N:15]=1)([OH:24])=[O:23]
参加物実験手順後処理出典と根拠反応ノート

参加物

5

反応物 2

HCID 14797Potassium HydroxideHCID 157184372-[trans-3-(3,3-Dimethyl-3-ethoxycarbonylpropyloxy)styryl]-4-isopropylthiazole

生成物 1

HCID 157184452-[trans-3-(3-Carboxy-3,3-dimethylpropyloxy)styryl]-4-isopropylthiazole収率 66.3%

試薬・触媒・溶媒 2

HCID 19865511Benzyltrimethylammonium hydroxide methanol触媒HCID 702Ethanol
溶媒
2 回

実験手順

To a solution of 200 mg of 2-[trans-3-(3,3-dimethyl-3-ethoxycarbonylpropyloxy)styryl]-4-isopropylthiazole dissolved in 5 ml of ethanol were added 2 ml of 10% aqueous potassium hydroxide solution and three drops of 40% benzyltrimethylammonium hydroxide methanol solution, and the mixture was refluxed for 1 hour to effect hydrolysis of the ester. After completion of the reaction, ethanol was evaporated under reduced pressure and the residue was adjusted to pH 1-2 with addition of 10% hydrochloric acid and then extracted with ethyl ether. After drying of anhydrous magnesium sulfate, the solvent was evaporated and the solid formed was recrystallized from methanol to give 123 mg (yield 66%) of the title compound.

後処理

  1. temperaturethe mixture was refluxed for 1 hour
  2. customwas evaporated under reduced pressure
  3. additionthe residue was adjusted to pH 1-2 with addition of 10% hydrochloric acid
  4. extractionextracted with ethyl ether
  5. dry with materialAfter drying of anhydrous magnesium sulfate
  6. customthe solvent was evaporated
  7. customthe solid formed
  8. customwas recrystallized from methanol

出典と根拠

ORDレコード
ord-b01298d2f61f4bfc8091e8fc4020f061
出典データセット
uspto-grants-1990_02
DOI
10.6084/m9.figshare.5104873.v1
特許番号
US04902700

反応ノート

読み込み中…

このページの内容参加物実験手順後処理出典と根拠反応ノート