Hexanoic anhydride → 8-chloro-1-(hydroxymethyl)-6-phenyl-4H-s-triazolo[4,3-a][1,4]benzodiazepine hexanoate

HRID 1199790

反応式

HRID 1199790 の反応式
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[N:11]3[C:12]([CH2:15][OH:16])=[N:13][N:14]=[C:10]3[CH2:9][N:8]=[C:7]([C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=3)[C:6]=2[CH:23]=1.[C:24]([O:31]C(=O)CCCCC)(=[O:30])[CH2:25][CH2:26][CH2:27][CH2:28][CH3:29]>O>[C:24]([OH:31])(=[O:30])[CH2:25][CH2:26][CH2:27][CH2:28][CH3:29].[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[N:11]3[C:12]([CH2:15][OH:16])=[N:13][N:14]=[C:10]3[CH2:9][N:8]=[C:7]([C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=3)[C:6]=2[CH:23]=1

参加物

4

反応物 2

HCID 74918Hexanoic anhydrideHCID 162244alpha-Hydroxyalprazolam

生成物 1

HCID 703596668-chloro-1-(hydroxymethyl)-6-phenyl-4H-s-triazolo[4,3-a][1,4]benzodiazepine hexanoate

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

In a manner similar to Example 12, a mixture of 8-chloro-1-(hydroxymethyl)-6-phenyl-4H-s-triazolo[4,3-a][1,4]benzodiazepine and hexanoic anhydride was heated on the water bath to give 8-chloro-1-(hydroxymethyl)-6-phenyl-4H-s-triazolo[4,3-a][1,4]benzodiazepine hexanoate (ester).

出典と根拠

ORDレコード
ord-f55ee58803374c00b0dcb9fb7f8b386f
出典データセット
uspto-grants-1990_02
特許番号
US04902794

関連ノート

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