Ethanol → 1-(3,5-Dichlorophenyl)-4-ethoxycarbonyl-5-pyrazolecarboxamide

HRID 1199831

反応式

HRID 1199831 の反応式
[C:1]([C:4]1[CH:5]=[N:6][N:7]([C:12]2[CH:17]=[C:16]([Cl:18])[CH:15]=[C:14]([Cl:19])[CH:13]=2)[C:8]=1[C:9]([NH2:11])=[O:10])([OH:3])=[O:2].[CH2:20](O)[CH3:21]>>[Cl:19][C:14]1[CH:13]=[C:12]([N:7]2[C:8]([C:9]([NH2:11])=[O:10])=[C:4]([C:1]([O:3][CH2:20][CH3:21])=[O:2])[CH:5]=[N:6]2)[CH:17]=[C:16]([Cl:18])[CH:15]=1

参加物

3

反応物 2

HCID 702EthanolHCID 1638961H-Pyrazole-4-carboxylic acid, 5-(aminocarbonyl)-1-(3,5-dichlorophenyl)-

生成物 1

HCID 144213121-(3,5-Dichlorophenyl)-4-ethoxycarbonyl-5-pyrazolecarboxamide

実験手順

Two g of the compound of Example 2 was suspended in 80 ml of absolute ethanol and hydrogen chloride gas was bubbled through for 5 minutes. The mixture was then heated under reflux for 2 hours and cooled, and was then filtered. The solids were collected and dried to obtain 1.25 g of the desired product, m.p. 164°-166°.

後処理

  1. customhydrogen chloride gas was bubbled through for 5 minutes
  2. temperatureThe mixture was then heated
  3. temperatureunder reflux for 2 hours
  4. temperaturecooled
  5. filtrationwas then filtered
  6. customThe solids were collected
  7. customdried

出典と根拠

ORDレコード
ord-123f1105a2a342c3be228e0137e6c3ff
出典データセット
uspto-grants-1990_02
特許番号
US04902808

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