Ethanol → 1-(3,5-Dichlorophenyl)-4-ethoxycarbonyl-5-pyrazolecarboxamide
反応式
[C:1]([C:4]1[CH:5]=[N:6][N:7]([C:12]2[CH:17]=[C:16]([Cl:18])[CH:15]=[C:14]([Cl:19])[CH:13]=2)[C:8]=1[C:9]([NH2:11])=[O:10])([OH:3])=[O:2].[CH2:20](O)[CH3:21]>>[Cl:19][C:14]1[CH:13]=[C:12]([N:7]2[C:8]([C:9]([NH2:11])=[O:10])=[C:4]([C:1]([O:3][CH2:20][CH3:21])=[O:2])[CH:5]=[N:6]2)[CH:17]=[C:16]([Cl:18])[CH:15]=1参加物
3
実験手順
Two g of the compound of Example 2 was suspended in 80 ml of absolute ethanol and hydrogen chloride gas was bubbled through for 5 minutes. The mixture was then heated under reflux for 2 hours and cooled, and was then filtered. The solids were collected and dried to obtain 1.25 g of the desired product, m.p. 164°-166°.
後処理
- customhydrogen chloride gas was bubbled through for 5 minutes
- temperatureThe mixture was then heated
- temperatureunder reflux for 2 hours
- temperaturecooled
- filtrationwas then filtered
- customThe solids were collected
- customdried
出典と根拠
- ORDレコード
- ord-123f1105a2a342c3be228e0137e6c3ff
- 出典データセット
- uspto-grants-1990_02
- 特許番号
- US04902808
反応ノート
読み込み中…