Methyl Isocyanate → HCID 15622814、化合物
反応式
[O:1]=[C:2]1[CH2:6][CH2:5][CH2:4][N:3]1[CH2:7][C:8]([N:10]1[CH2:15][CH2:14][NH:13][CH2:12][CH2:11]1)=[O:9].[CH3:16][N:17]=[C:18]=[O:19]>C(Cl)Cl>[CH3:16][NH:17][C:18]([N:13]1[CH2:12][CH2:11][N:10]([C:8](=[O:9])[CH2:7][N:3]2[CH2:4][CH2:5][CH2:6][C:2]2=[O:1])[CH2:15][CH2:14]1)=[O:19]参加物
4
実験手順
700 mg (3.31 mmol) of (2-oxopyrrolidin-1-yl)acetylpiperazine was dissolved in 10.5 ml of CH2Cl2, and 0.215 ml (3.64 mmol) of methyl isocyanate was added to the mixture under ice-cooling, and the mixture was warmed to room temperature and stirred for 1 hr. After evaporating CH2Cl2, the precipitated crystals were washed with Et2O and collected by filtration. By recrystallizing from EtOH-Et2O, 856 mg of the objective compound (yield: 96.3%) was obtained as colorless prisms.