Methyl 4-fluorobenzoylacetate → HCID 19864531、化合物
反応式
[F:1][C:2]1[CH:14]=[CH:13][C:5]([C:6]([CH2:8][C:9]([O:11][CH3:12])=[O:10])=[O:7])=[CH:4][CH:3]=1.[CH3:15][C:16]1[N:17]([CH2:25][CH2:26][CH2:27]CO)[C:18]2[CH:23]=[CH:22][N:21]=[CH:20][C:19]=2[N:24]=1>C1(C)C=CC=CC=1>[F:1][C:2]1[CH:3]=[CH:4][C:5]([C:6](=[O:7])[CH2:8][C:9]([O:11][CH2:12][CH2:27][CH2:26][CH2:25][N:17]2[C:18]3[CH:23]=[CH:22][N:21]=[CH:20][C:19]=3[N:24]=[C:16]2[CH3:15])=[O:10])=[CH:13][CH:14]=1参加物
4
実験手順
Methyl 4-fluorobenzoylacetate (0.78 g, 4 mM) and 4-(2-methylimidazo[4,5-c]pyrid-1-yl)butanol (0.82 g, 4 mM--see Preparation 16) were heated at reflux in toluene (100 cm3) allowing the toluene to reduce to about 20 cm3 over a period of 2 hours. The remaining toluene was removed in vacuo and the residue purified by column chromatography on silica (Merck "Kieselgel 60"--Trade Mark) eluting with dichloromethane:methanol 19:1. Evaporation of the appropriate fractions gave the title compound as a colourless oil, (1.05 g, 71%).